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rotarod  (Med Associates Inc)


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    Med Associates Inc rotarod
    Rotarod, supplied by Med Associates Inc, used in various techniques. Bioz Stars score: 96/100, based on 983 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rotarod/product/Med Associates Inc
    Average 96 stars, based on 983 article reviews
    rotarod - by Bioz Stars, 2026-03
    96/100 stars

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    Rotarod assessment of strength stamina and coordination. At one year of age, mice were assessed for time to fall on an accelerating rotarod treadmill. The average latency to fall is represented by solid black circles (control), squares (vehicle-treated), or triangles (drug-treated). In the C9-149R model, average results are shown as C9-2R (open column), vehicle-treated (blue column), and drug-treated (purple column). There was no significant difference in performance between vehicle-treated groups (glycine or saline) and C9-2R controls (upper panel). For the TDP-43 Q331K model, average results are shown as WT (open column), vehicle-treated (green column), and drug-treated (red column). Motor performance was significantly reduced in all TDP-43 Q331K cohorts compared to WT controls ( p < 0.0001, ****, one-way ANOVA with Tukey’s post hoc test). Error bars represent ±SD.

    Journal: International Journal of Molecular Sciences

    Article Title: PPAR-Delta Agonist Therapies Did Not Rescue Hallmark Disease Phenotypes in Two Sets of Preclinical Trials in ALS TDP-43 and C9orf72 Model Mice

    doi: 10.3390/ijms27041820

    Figure Lengend Snippet: Rotarod assessment of strength stamina and coordination. At one year of age, mice were assessed for time to fall on an accelerating rotarod treadmill. The average latency to fall is represented by solid black circles (control), squares (vehicle-treated), or triangles (drug-treated). In the C9-149R model, average results are shown as C9-2R (open column), vehicle-treated (blue column), and drug-treated (purple column). There was no significant difference in performance between vehicle-treated groups (glycine or saline) and C9-2R controls (upper panel). For the TDP-43 Q331K model, average results are shown as WT (open column), vehicle-treated (green column), and drug-treated (red column). Motor performance was significantly reduced in all TDP-43 Q331K cohorts compared to WT controls ( p < 0.0001, ****, one-way ANOVA with Tukey’s post hoc test). Error bars represent ±SD.

    Article Snippet: Mice were assessed for time to fall on an accelerating rotarod treadmill (ENV-574M, Med Associates, Inc., St. Albans, VT, USA) set to increase from 4 to 40 rpm over four trials, with a maximum duration of 300 s per trial.

    Techniques: Control, Saline